Hydrochloric Acid → 6-Fluoro-2-methyl-2,3-dihydroquinolin-4(1H)-one

HRID 1287621노트

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HRID 1287621 반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[O:12]C.[CH3:14][Li].Cl>O1CCCC1.C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]([CH3:14])[CH2:6][C:5]2=[O:12]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 214081816-Fluoro-4-methoxyquinolineHCID 178418348HCID 178418348, 화합물2회

생성물 1

HCID 214081896-Fluoro-2-methyl-2,3-dihydroquinolin-4(1H)-one수율 37%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
-20 °C

실험 절차

A stirred solution of 25.8 g (0.146 mole) of 6-fluoro-4-methoxyquinoline from example 3 in 300 ml of tetrahydrofuran was heated under a nitrogen atmosphere to its reflux temperature and then cooled to -20° C. To the cold solution was added 90 ml of 182 M methyl lithium in diethyl ether over a period of 0.5 hour. After adding 40 ml of the solution, the reaction temperature was allowed to rise to 0° C. After the addition of methyl lithium was completed, the reaction temperature was allowed to rise to 15° C. The solution was then poured into 1200 ml of a mixture of ice water and hydrochloric acid. After stirring for 0.5 hour the mixture was extracted with about 1200 ml of diethyl ether. The organic layer was dried, filtered and evaporated in vacuo to provide a yellow solid. The product was recrystallized from carbon tetrachloride to give 9.5 g. (37% yield) of 6-fluoro-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline.

후처리

  1. temperaturereflux temperature
  2. customto rise to 0° C
  3. customto rise to 15° C
  4. extractionwas extracted with about 1200 ml of diethyl ether
  5. customThe organic layer was dried
  6. filtrationfiltered
  7. customevaporated in vacuo
  8. customto provide a yellow solid
  9. customThe product was recrystallized from carbon tetrachloride
  10. customto give 9.5 g

출처 및 근거

ORD 기록
ord-73cbcd27466a4d74a49e83ceb3821f48
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03985753

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