Hydrochloric Acid → Methyl 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate

HRID 1287768

반응식

HRID 1287768 반응식
[CH2:1]([NH:5][C:6]1[CH:7]=[C:8]([CH:12]=[C:13]([S:22](=[O:25])(=[O:24])[NH2:23])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:9]([OH:11])=[O:10])[CH2:2][CH2:3][CH3:4].Cl.[CH3:27]O>>[CH3:27][O:10][C:9](=[O:11])[C:8]1[CH:12]=[C:13]([S:22](=[O:25])(=[O:24])[NH2:23])[C:14]([O:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[C:6]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[CH:7]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2471Bumetanide

생성물 1

HCID 16657174Methyl 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate

실험 절차

A mixture of 3-n-butylamino-4-phenoxy-5-sulphamyl-benzoic acid (3 g) and methanol (60 ml) was saturated with gaseous hydrogen chloride. The reaction mixture was allowed to warm during the saturation. After cooling and standing for 5 hours, the reaction mixture was evaporated in vacuo, and the residue was recrystallized from methanol (12 ml), whereby the methyl-3-n-butylamino-4-phenoxy-5-sulphamyl-benzoate was obtained with a melting point of 148° C.

후처리

  1. temperatureto warm during the saturation
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated in vacuo
  4. customthe residue was recrystallized from methanol (12 ml), whereby the methyl-3-n-butylamino-4-phenoxy-5-sulphamyl-benzoate
  5. customwas obtained with a melting point of 148° C.

출처 및 근거

ORD 기록
ord-94409f5fc79e43f2afecdfb4bc19f5c4
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03985777

연결된 노트

불러오는 중…