4-Hydroxybenzaldehyde → p-(Octyloxy)benzaldehyde

HRID 128778

반응식

HRID 128778 반응식
[H-].[Na+].[OH:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1.Br[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]>CN(C)C=O>[CH2:13]([O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[CH:6][CH:5]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 1264-HydroxybenzaldehydeHCID 81401-BromooctaneHCID 24758Sodium hydride

생성물 1

HCID 90358p-(Octyloxy)benzaldehyde

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Sodium hydride (4.2 g of 60% dispersion in oil) is added to a solution of 4-hydroxybenzaldehyde (12.2 g) in dimethylformamide. The mixture is stirred for 30 min, and 1-bromooctane (18 ml) is added. The reaction mixture is stirred at 90° for five hours, cooled, and the solvent removed in vacuo. The residue is shaken with water, and extracted with three portions of hexane. The hexane extracts are dried, concentrated, and distilled in vacuo to provide 20.3 g of 4-octyloxybenzaldehyde.

후처리

  1. stirringThe reaction mixture is stirred at 90° for five hours
  2. temperaturecooled
  3. customthe solvent removed in vacuo
  4. stirringThe residue is shaken with water
  5. extractionextracted with three portions of hexane
  6. dry with materialThe hexane extracts are dried
  7. concentrationconcentrated
  8. distillationdistilled in vacuo

출처 및 근거

ORD 기록
ord-9d34e36668c044eab835a9a616aded82
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464865

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