Ethyl formate → N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

HRID 1287845노트

반응식

HRID 1287845 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:11]([NH2:23])[CH:10]=1)=[O:8].[CH:24](OCC)=[O:25]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:11]([NH:23][CH:24]=[O:25])[CH:10]=1)=[O:8]

참가 물질

3

반응물 2

HCID 8025Ethyl formateHCID 538809743-Amino-4-benzyloxyphenyl 2-pyridyl ketone

생성물 1

HCID 53784995N-[2-(Benzyloxy)-5-(pyridine-2-carbonyl)phenyl]formamide

실험 절차

A mixture of 10.0 g (32.8 mmol) of 3-amino-4-benzyloxyphenyl 2-pyridyl ketone and 200 ml of ethyl formate is refluxed with stirring for 24 hours. The reaction mixture is evaporated and the residue is dissolved in methylene chloride, then is washed with dilute HCl and saturated saline solution. The dried organic phase is evaporated to give 4-benzyloxy-3-formamidophenyl 2-pyridyl ketone.

후처리

  1. temperatureis refluxed
  2. customThe reaction mixture is evaporated
  3. dissolutionthe residue is dissolved in methylene chloride
  4. washis washed with dilute HCl and saturated saline solution
  5. customThe dried organic phase is evaporated

출처 및 근거

ORD 기록
ord-1f66b970818545b9a5dd8f3b7f9dc50e
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03985887

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