Hydrochloric Acid → 1,3-Dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine]

반응식

O[C:2]1([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=2[CH2:16][OH:17])[CH2:7][CH2:6][N:5]([CH3:8])[CH2:4][CH2:3]1.Cl>>[CH3:8][N:5]1[CH2:4][CH2:3][C:2]2([C:9]3[C:10](=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=3)[CH2:16][O:17]2)[CH2:7][CH2:6]1

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 86733527HCID 86733527, 화합물

생성물 1

HCID 215068121,3-Dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine]

실험 절차

Treatment of 4-hydroxy-4-(α-hydroxy-5-methyl-2-tolyl)-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro-1',5-dimethylspiro[isobenzofuran-1,4'-piperidine].

출처 및 근거

ORD 기록: ord-0ce4b6ab1ad54542b382ee7c49934f85
출처 데이터셋: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US03985889

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