Hydrochloric Acid → 1,3-Dihydro5-fluoro-1'-methylspiro[isobenzofuran-1,4'-piperidine]
반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:10]2([OH:17])[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[C:6]([CH2:8]O)[CH:7]=1.Cl>>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[C:10]1([CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]1)[O:17][CH2:8]2참가 물질
3
실험 절차
Treatment of 4-(5-fluoro-α-hydroxy-2-tolyl)-4-hydroxy-1-methylpiperidine with hydrochloric acid by the method described in Example 16d provides 1,3-dihydro5-fluoro-1'-methylspiro[isobenzofuran-1,4'-piperidine].
출처 및 근거
- ORD 기록
- ord-fce8ec83fe3149a6a16cdada47140453
- 출처 데이터셋
- uspto-grants-1976_10
- 특허 번호
- US03985889
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