Benzene → HCID 21503115, 화합물

HRID 1287944노트

반응식

HRID 1287944 반응식
Cl.[CH2:2]([O:9][CH2:10][C:11]([CH3:15])([OH:14])[CH2:12][OH:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:16]([O:21][CH2:22][CH3:23])(=[O:20])[C:17]([CH3:19])=O.C1C=CC=CC=1>O>[CH2:2]([O:9][CH2:10][C:11]1([CH3:15])[CH2:12][O:13][C:17]([CH3:19])([C:16]([O:21][CH2:22][CH3:23])=[O:20])[O:14]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 241BenzeneHCID 313Hydrochloric AcidHCID 12041Ethyl pyruvateHCID 561596HCID 561596, 화합물

생성물 1

HCID 21503115HCID 21503115, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
90 °C

실험 절차

Dry hydrogen chloride gas was passed into a mixture of 3-benzyloxy-2-methylpropane-1,2-diol (14.9 grams) and ethyl pyruvate (9.15 grams) for 1 hour. The mixture was heated at 90° C for a further 1 hour and then cooled to 50° C. Benzene (100 milliliters) was added to the mixture and the water formed in the reaction was removed azeotropically. The cooled solution was washed with potassium carbonate solution and dried. The solvent was removed under reduced pressure and the residue was fractionally distilled to yield the desired product boiling point 124-126° C at 0.3 Torr.

후처리

  1. temperaturecooled to 50° C
  2. customwas removed azeotropically
  3. washThe cooled solution was washed with potassium carbonate solution
  4. customdried
  5. customThe solvent was removed under reduced pressure
  6. distillationthe residue was fractionally distilled

출처 및 근거

ORD 기록
ord-193c57e2116f41b98b2d7f0c42b1b34e
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03986860

반응 노트

불러오는 중…