Ammonia → N-(2-phenoxypropyl)phenylacetamidine p-toluenesulphonate

HRID 1288227

반응식

HRID 1288227 반응식
[O:1]([CH:8]([CH3:11])[CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12]1([CH3:22])[CH:17]=[CH:16][C:15]([S:18]([OH:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1.[C:23]1([CH2:29][C:30](N)=[NH:31])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.N>C(O)C.CCOCC>[C:12]1([CH3:22])[CH:13]=[CH:14][C:15]([S:18]([OH:21])(=[O:19])=[O:20])=[CH:16][CH:17]=1.[O:1]([CH:8]([CH3:11])[CH2:9][NH:10][C:30](=[NH:31])[CH2:29][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 222AmmoniaHCID 37183552-Phenoxy-1-propanamineHCID 21504266Phenylacetamidine p-toluenesulphonate

생성물 1

HCID 178457535N-(2-phenoxypropyl)phenylacetamidine p-toluenesulphonate

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3283Diethyl Ether용매

실험 절차

2-Phenoxypropylamine (6.0 g.) was added to a suspension of phenylacetamidine p-toluenesulphonate (12.4 g.) in absolute ethanol (20 ml.). The mixture was heated to reflux for 4 hours by which time the initially vigorous evolution of ammonia had practically ceased. The resulting solution was cooled somewhat and diluted with ether to give an oil which rapidly crystallised on scratching. The solid was filtered and recrystallised from a mixture of ethanol and water to give N-(2-phenoxypropyl)phenylacetamidine p-toluenesulphonate, m.p. 127°-129°.

후처리

  1. temperatureThe mixture was heated
  2. temperatureThe resulting solution was cooled somewhat
  3. customto give an oil which
  4. customrapidly crystallised
  5. filtrationThe solid was filtered
  6. customrecrystallised from a mixture of ethanol and water

출처 및 근거

ORD 기록
ord-719982c498de4dda8dc06af693ee3417
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987158

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