Water → 2-Phenoxy-1-propanamine

HRID 1288230

반응식

HRID 1288230 반응식
[O:1]([CH:8]([CH3:11])[C:9]#[N:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[O:1]([CH:8]([CH3:11])[CH2:9][NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 190944362-PhenoxypropanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 37183552-Phenoxy-1-propanamine

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 2-phenoxypropionitrile (11.0 s.) in dry ether (50 ml.) was added dropwise to a stirred suspension of lithium aluminium hydride (3.8 g.) in dry ether (50 ml.). The mixture was then heated to reflux for 3 hours, cooled and treated cautiously (vigorous stirring) with water (3.8 ml.) then with 15% aqueous sodium hydroxide (3.8 ml.) and finally with water (11.4 ml.). The mixture was stirred for 20 minutes and filtered. The filtrate was dried over anhydrous potassium carbonate and evaporated. The residue was distilled under water-pump vacuum to give pure 2-phenoxypropylamine, b.p. 115°-116°/15 mm.

후처리

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 3 hours
  3. temperaturecooled
  4. additiontreated cautiously
  5. filtrationfiltered
  6. dry with materialThe filtrate was dried over anhydrous potassium carbonate
  7. customevaporated
  8. distillationThe residue was distilled under water-pump vacuum

출처 및 근거

ORD 기록
ord-6a922e13d3f2425987de5b5a5296ee3b
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987158

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