Water → 2-Propanamine, 1-(3-methylphenoxy)-

HRID 1288233노트

반응식

HRID 1288233 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[O:5][CH2:6][C:7](=[N:9]O)[CH3:8].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][CH:13]=1)[O:5][CH2:6][CH:7]([NH2:9])[CH3:8]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 85437759HCID 85437759, 화합물

생성물 1

HCID 122988962-Propanamine, 1-(3-methylphenoxy)-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of 1-(3-methylphenoxy)propan-2-one oxime (13.7 g.) in dry ether (100 ml.) was added dropwise, over 45 minutes, to a stirred, refluxing mixture of lithium aluminium hydride (5.85 g.) in dry ether (200 ml.). Stirring and heating were continued for 4 hours and the mixture was cooled and treated cautiously with water (5.8 ml.) followed by 15% aqueous sodium hydroxide (5.8 ml.), and finally, water (17.5 ml.). The mixture was stirred for 30 minutes and then filtered. The filtrate was dried over anhydrous potassium carbonate and evaporated. The residue was distilled to give 1-(3-methylphenoxy)prop-2-ylamine, b.p. 124°-128°/13 mm.

후처리

  1. temperaturerefluxing
  2. temperatureheating
  3. temperaturethe mixture was cooled
  4. stirringThe mixture was stirred for 30 minutes
  5. filtrationfiltered
  6. dry with materialThe filtrate was dried over anhydrous potassium carbonate
  7. customevaporated
  8. distillationThe residue was distilled

출처 및 근거

ORD 기록
ord-ab449766ab784b499fd2ecb646f60432
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987158

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