HCID 21950481, 화합물 → 2-(Methanesulfonyl)benzonitrile

HRID 1288266노트

반응식

HRID 1288266 반응식
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH2:9])=O)(=[O:4])=[O:3]>P(Cl)(Cl)(Cl)=O>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]#[N:9])(=[O:3])=[O:4]

참가 물질

3

반응물 1

HCID 21950481HCID 21950481, 화합물

생성물 1

HCID 223462902-(Methanesulfonyl)benzonitrile수율 87.3%

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

2-Methanesulphonylbenzamide (34 g.) was added to phosphorus oxychloride (100 ml.) and the mixture was refluxed for 90 minutes. The excess of phosphorus oxychloride was evaporated in vacuo, and the oily residue was treated with water (200 ml.), with ice cooling. The solid which separated was filtered off, washed with water and recrystallised from ethanol to give 2-methanesulphonylbenzonitrile (27 g.), m.p. 105°-106° C.

후처리

  1. temperaturethe mixture was refluxed for 90 minutes
  2. customThe excess of phosphorus oxychloride was evaporated in vacuo
  3. additionthe oily residue was treated with water (200 ml.), with ice cooling
  4. customThe solid which separated
  5. filtrationwas filtered off
  6. washwashed with water
  7. customrecrystallised from ethanol

출처 및 근거

ORD 기록
ord-394b98742ce743418c8da40afff7a674
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987160

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