Hydrochloric Acid → 9-Methyltetrazolo[1,5-a]quinoxaline

HRID 1288325노트

반응식

HRID 1288325 반응식
Cl[C:2]1[CH:3]=[N:4][C:5]2[C:10]([N:11]=1)=[C:9]([CH3:12])[CH:8]=[CH:7][CH:6]=2.[N-:13]=[N+:14]=[N-:15].[Na+].Cl>C(O)C>[CH3:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[N:11]1[N:13]=[N:14][N:15]=[C:2]1[CH:3]=[N:4]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 33557Sodium AzideHCID 215049212-Chloro-8-methylquinoxaline

생성물 1

HCID 215048979-Methyltetrazolo[1,5-a]quinoxaline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The crude 3-chloro-5-methylquinoxaline obtained in the step above was stirred for 3 hours at reflux temperature in 75 ml. of ethanol containing 1.8 g. of sodium azide and 20 ml. of 1N HCl. When the reaction mixture was cooled, the product precipitated as needles. Recrystallization of the product from ethanol produced highly purified 9-methyltetrazolo[1,5-a]quinoxaline, m.p. 166°-68° C. The product was identified by NMR analysis and by elemental microanalysis.______________________________________ Theoretical FoundC 58.37% 58.11%H 3.81 3.98N 37.82 37.60______________________________________

후처리

  1. temperatureat reflux temperature in 75 ml
  2. temperatureWhen the reaction mixture was cooled
  3. customthe product precipitated as needles
  4. customRecrystallization of the product from ethanol

출처 및 근거

ORD 기록
ord-a6bd63ae652744e8b570c1052848e750
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987196

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