Acetic Acid → Methyl 7-[acetyl(4-hydroxynonyl)amino]heptanoate

HRID 1288357노트

반응식

HRID 1288357 반응식
[N+](=[CH2:3])=[N-].[OH:4][CH:5]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:6][CH2:7][CH2:8][N:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[C:10](=[O:12])[CH3:11].C(O)(=O)C>CCOCC>[OH:4][CH:5]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:6][CH2:7][CH2:8][N:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([O:21][CH3:3])=[O:20])[C:10](=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 215039297-[Acetyl(4-hydroxynonyl)amino]heptanoic acid

생성물 1

HCID 21503968Methyl 7-[acetyl(4-hydroxynonyl)amino]heptanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of diazomethane (approx. 2.5 g., 0.06 mole) in ether (100 ml.) is mixed with a solution of 7-[N-(4-hydroxynonyl)acetamido]heptanoic acid (9.8 g., 0.03 mole) (Example 1, Step C) in ether (50 ml.). The resulting solution is allowed to stand 4 hours at room temperature. Acetic acid is then added to destroy the excess diazomethane and the solution is washed with dilute sodium bicarbonate solution and water and dried over sodium sulfate. Evaporation of volatile materials at reduced pressure yields methyl 7-[N-(4-hydroxynonyl)acetamido]-heptanoate as a viscous oil.

후처리

  1. customto destroy the excess diazomethane
  2. washthe solution is washed with dilute sodium bicarbonate solution and water
  3. dry with materialdried over sodium sulfate
  4. customEvaporation of volatile materials at reduced pressure

출처 및 근거

ORD 기록
ord-c447b90e60f24bd4bbd58883649da5f2
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987091

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