Glycidol → 3-(Octadecylamino)propane-1,2-diol

HRID 128894

반응식

HRID 128894 반응식
[CH2:1]([NH2:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:20]1[O:22][CH:21]1[CH2:23][OH:24]>CO>[CH2:1]([NH:19][CH2:20][CH:21]([OH:22])[CH2:23][OH:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

4

반응물 2

HCID 11164GlycidolHCID 15793Octadecylamine

생성물 1

HCID 1200883-(Octadecylamino)propane-1,2-diol수율 95.9%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

Octadecylamine (18 g) was dissolved in 200 ml methanol and heated to 60° C. Glycidol (4.95 g) was added dropwise under constant stirring over one and half hours. The reaction mixture was kept under reflux for one additional hour, and then cooled to room temperature, and evaporated to dryness, resulting in 22 g white solid material. This was then recrystallized from hexane, to yield ODP, mp 81°-83° C.

후처리

  1. temperatureunder reflux for one additional hour
  2. temperaturecooled to room temperature
  3. customevaporated to dryness

출처 및 근거

ORD 기록
ord-f27d6f854cac411c9ea3585343c87e9f
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466438

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