2-Bromophenol → 1-Bromo-2-(2-methylpropoxy)benzene

HRID 1289178노트

반응식

HRID 1289178 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C([O-])([O-])=O.[K+].[K+].I[CH2:16][CH:17]([CH3:19])[CH3:18]>CC(C)=O>[CH2:16]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1])[CH:17]([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 72442-BromophenolHCID 10556Isobutyl iodideHCID 11430Potassium Carbonate

생성물 1

HCID 189257731-Bromo-2-(2-methylpropoxy)benzene수율 25%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 2-bromophenol (0.67 ml, 5.8 mmol) in 25 ml acetone was added K2CO3 (2.0 g, 14.5 mmol) and 1-iodo-2-methylpropane (0.75 ml, 6.4 mmol). The reaction mixture was heated to reflux for 19 h, cooled to ambient temperature and filtered. The solvent was removed under reduced pressure and the residue was taken up in EtOAc. The organic phase was washed with 1N NaOH×2, water and brine. Drying over Na2 SO4 afforded 330 mg (25%) of 2-isobutoxybromobenzene.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 19 h
  3. filtrationfiltered
  4. customThe solvent was removed under reduced pressure
  5. washThe organic phase was washed with 1N NaOH×2, water and brine
  6. customDrying over Na2 SO4

출처 및 근거

ORD 기록
ord-1a858d066ef94350b5e480fb11b0bdcb
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747540

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