Methyl iodide → 2-Methoxy-4-phenoxybromobenzene

HRID 1289181노트

반응식

HRID 1289181 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:4][C:3]=1[OH:15].[C:16]([O-])([O-])=O.[K+].[K+].IC>CC(C)=O>[CH3:16][O:15][C:3]1[CH:4]=[C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:7][C:2]=1[Br:1]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 189257712-Bromo-5-phenoxyphenol

생성물 1

HCID 189257722-Methoxy-4-phenoxybromobenzene수율 92.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 2-bromo-5-phenoxyphenol (0.38 g, 1.4 mmol) in 6 ml acetone was added K2CO3 (0.58 g, 4.2 mmol) and iodomethane (0.26 ml, 4.2 mmol). The-reaction mixture was heated to reflux for 8 h, cooled to ambient temperature and filtered. The solvent was removed under reduced pressure and the residue was taken up in EtOAc. The organic phase was washed with 1N NaOH, water and brine. Drying over Na2SO4 afforded 0.36 g (92%) of 2-methoxy-4-phenoxybromobenzene.

후처리

  1. customThe-reaction mixture
  2. temperaturewas heated
  3. temperatureto reflux for 8 h
  4. filtrationfiltered
  5. customThe solvent was removed under reduced pressure
  6. washThe organic phase was washed with 1N NaOH, water and brine
  7. dry with materialDrying over Na2SO4

출처 및 근거

ORD 기록
ord-5df851b9137742cdb02a7035877fd118
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747540

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