Methyl alpha-amino-p-methoxycarbonylmethylphenylacetate → (RS)-alpha-amino-p-carboxymethylphenylacetic acid

HRID 1289240노트

반응식

HRID 1289240 반응식
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:9][CH:8]=1)[C:3]([O:5]C)=[O:4]>Cl>[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]

참가 물질

3

반응물 1

HCID 54294376Methyl alpha-amino-p-methoxycarbonylmethylphenylacetate

생성물 1

HCID 18925125(RS)-alpha-amino-p-carboxymethylphenylacetic acid수율 99%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A suspension of methyl α-amino-p-methoxycarbonylmethylphenylacetate (2.3 g, 7 mmol) in 60 ml of 6N HCl was refluxed for 12 hours. After cooling white needles were collected. The aqueous layers were extracted with ethyl acetate. The organic layers were evaporated and the solids combined to give (RS)-α-amino-p-carboxymethylphenylacetic acid (1.45 g, 83%);

후처리

  1. temperaturewas refluxed for 12 hours
  2. temperatureAfter cooling white needles
  3. customwere collected
  4. extractionThe aqueous layers were extracted with ethyl acetate
  5. customThe organic layers were evaporated

출처 및 근거

ORD 기록
ord-381463ce4d2a42529a84fb8a8dcb4c07
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747499

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