Carbon Dioxide → 4-(Decyloxy)-3-fluorobenzoic acid

HRID 1289339노트

반응식

HRID 1289339 반응식
C([Li])CCC.Br[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:9]([F:24])[CH:8]=1.[C:25](=[O:27])=[O:26].Cl>C1COCC1.CCOCC>[CH2:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([C:25]([OH:27])=[O:26])=[CH:8][C:9]=1[F:24])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

참가 물질

7

반응물 4

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 146925094-Decyloxy-3-fluorophenyl bromideHCID 178418339Butyllithium

생성물 1

HCID 6399744-(Decyloxy)-3-fluorobenzoic acid

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of n-butyllithium was added dropwise to a stirred, cooled (-78° C.) solution of compound of step 2.1 in dry THF. The mixture was maintained under these conditions for 40 mins and then poured into a slurry of dry ether and cardice. The solution was acidified with 36% HCl, washed with water and dried (magnesium sulphate). The solvent was removed to yield a white solid.

후처리

  1. temperatureThe mixture was maintained under these conditions for 40 mins
  2. washwashed with water
  3. dry with materialdried (magnesium sulphate)
  4. customThe solvent was removed
  5. customto yield a white solid

출처 및 근거

ORD 기록
ord-1090e088da22497eb8bcb2419e46c059
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750050

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