Hydrochloric Acid → 2,2-Bis(6-benzyloxyhexyl)acetic acid

HRID 1289384노트

반응식

HRID 1289384 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH:15]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:16]([O:18]CC)=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].Cl>CO>[CH2:28]([O:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH:15]([CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:16]([OH:18])=[O:17])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 18920832Ethyl 2,2-bis(6-benzyloxyhexyl)acetate

생성물 1

HCID 189208392,2-Bis(6-benzyloxyhexyl)acetic acid수율 55%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

First, 12 g of ethyl 2,2-bis(6-benzyloxyhexyl)acetate, 250 ml of methanol, and 100 ml of an aqueous solution containing 16.8 g of 85% potassium hydroxide were placed in a 500 ml flask. Then, the mixture was stirred under reflux for 2 hours. The reaction mixture was poured into diluted hydrochloric acid, and an organic layer was extracted with ether. The ether layer was washed with water and dried over anhydrous sodium sulfate. Thereafter, the solvent was distilled away. The residue was recrystallized from a mixed solvent of hexane and acetone to obtain 6.2 g of 2,2-bis(6-benzyloxyhexyl)acetic acid (Y: 55%).

후처리

  1. customwere placed in a 500 ml flask
  2. temperatureunder reflux for 2 hours
  3. extractionan organic layer was extracted with ether
  4. washThe ether layer was washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationThereafter, the solvent was distilled away
  7. customThe residue was recrystallized from a mixed solvent of hexane and acetone

출처 및 근거

ORD 기록
ord-b8cb1134b8f24782907061084f72bf38
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750213

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