Chloroacetyl chloride → Chloroacetic acid morpholine carboxamide

HRID 1289416

반응식

HRID 1289416 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].C[N:7]1CC[O:10]CC1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>ClCCl>[N:13]1([C:3]([NH2:7])=[O:4])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Cl:1][CH2:2][C:3]([OH:4])=[O:10]

참가 물질

5

반응물 3

HCID 6577Chloroacetyl chlorideHCID 79724-MethylmorpholineHCID 8083Morpholine

생성물 1

HCID 88103447Chloroacetic acid morpholine carboxamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate invacuo to obtain chloroacetic acid morpholine carboxamide.

후처리

  1. temperatureCool in an ice-bath
  2. extractionExtract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
  3. dry with materialDry the organic layer over Na2SO4
  4. filtrationfilter
  5. customevaporate invacuo

출처 및 근거

ORD 기록
ord-d43abefa04ed4285b98b38b72f6092c2
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750521

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