Chloroacetyl chloride → Chloroacetic acid morpholine carboxamide
반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].C[N:7]1CC[O:10]CC1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>ClCCl>[N:13]1([C:3]([NH2:7])=[O:4])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Cl:1][CH2:2][C:3]([OH:4])=[O:10]참가 물질
5
실험 절차
Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate invacuo to obtain chloroacetic acid morpholine carboxamide.
후처리
- temperatureCool in an ice-bath
- extractionExtract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
- dry with materialDry the organic layer over Na2SO4
- filtrationfilter
- customevaporate invacuo
출처 및 근거
- ORD 기록
- ord-d43abefa04ed4285b98b38b72f6092c2
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05750521
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