Acetyl chloride → HCID 20077196, 화합물

HRID 1289446노트

반응식

HRID 1289446 반응식
[Cl-].[Al+3].[Cl-].[Cl-].[CH2:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7][CH:6]1[CH2:14][C:15]([O:17][CH3:18])=[O:16].[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)Cl>[C:19]([C:10]1[CH:9]=[C:8]2[C:13](=[CH:12][CH:11]=1)[CH2:5][CH:6]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH2:7]2)(=[O:21])[CH3:20]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 14090225Methyl (2,3-dihydro-1H-inden-2-yl)acetate

생성물 1

HCID 20077196HCID 20077196, 화합물수율 91%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Added to 160 ml of methylene chloride were 52.9 g (0.388 mol) of anhydrous aluminum chloride. While chilling with ice water, a solution of 25.03 g (0.132 mol) of methyl (indan-2-yl)acetate in 40 ml of methylene chloride was added dropwise to the solution, followed by the addition of 13.1 ml (0.185 mol) of acetyl chloride. After stirring the mixture at the same temperature for 40 minutes, the reaction mixture was poured into ice water to take out an organic layer separated. After the organic layer was washed with water and dried, the solvent was distilled off under reduced pressure. The resultant residue was purified by column chromatography on silica gel (ethyl acetate-hexane=1:2), thereby obtaining 27.8 g of an oily substance. Yield: 91%.

후처리

  1. customseparated
  2. washAfter the organic layer was washed with water
  3. customdried
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe resultant residue was purified by column chromatography on silica gel (ethyl acetate-hexane=1:2)
  6. customobtaining 27.8 g of an oily substance

출처 및 근거

ORD 기록
ord-023ea0be0b2840d58d75a70c83a3d725
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750524

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