L-Tartaric acid → HCID 178485756, 화합물

HRID 1290077노트

반응식

HRID 1290077 반응식
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:59])(=[O:58])[C@@H:51]([C@H:53]([C:55]([OH:57])=[O:56])[OH:54])[OH:52]>C(OCC)(=O)C.C(O)C>[C:55]([C@@H:53]([C@H:51]([C:50]([OH:59])=[O:58])[OH:52])[OH:54])([OH:57])=[O:56].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 444305L-Tartaric acidHCID 178485751HCID 178485751, 화합물

생성물 1

HCID 178485756HCID 178485756, 화합물수율 68.7%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매2회

실험 절차

The compound (300 mg) obtained in Example 1 was dissolved in ethyl acetate (4.5 ml) and a solution of L-tartaric acid (66 mg) in ethyl acetate (5 ml) and ethanol (0.5 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 251 mg of the title compound as white crystals (see Table 16).

후처리

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-e6223c0ac8df4c57b301df180c926246
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750696

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