Potassium Carbonate → 8-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine

HRID 1290159

반응식

HRID 1290159 반응식
[OH:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[CH2:20][CH2:21]OS(C)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[CH2:20][CH2:21][O:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 8209532-Methylimidazo[1,2-a]pyridin-8-olHCID 155656222-(2,6-Dichlorophenyl)ethyl methanesulfonate

생성물 1

HCID 189233368-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine수율 23.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
70 °C

실험 절차

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (296 mg), 1,3-dichloro-2-(2-mesyloxyethyl)benzene (645 mg) and potassium carbonate (828 mg) in N,N-dimethylformamide (12 ml) was stirred for 6 hours at 70° C. The mixture was treated according to a similar manner to that of Preparation 16 to give 8-[2-(2,6-dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine (150 mg).

후처리

  1. additionThe mixture was treated
  2. customof Preparation 16

출처 및 근거

ORD 기록
ord-e000f68925e64e869fe194b41ff6db91
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750699

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