Hydrochloric Acid → 8-(3-Amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride

HRID 1290170노트

반응식

HRID 1290170 반응식
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([N+:20]([O-])=O)[C:14]=3[Cl:23])[C:5]2=[N:4][C:3]=1[CH3:24].[ClH:25]>[Fe].CO>[ClH:19].[ClH:25].[NH2:20][C:15]1[C:14]([Cl:23])=[C:13]([C:18]([Cl:19])=[CH:17][CH:16]=1)[CH2:12][O:11][C:10]1[C:5]2[N:6]([C:2]([Br:1])=[C:3]([CH3:24])[N:4]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 117969163-Bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine

생성물 1

HCID 189233178-(3-Amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride

시약·촉매·용매 2

HCID 23925Iron촉매HCID 887Methanol용매

실험 절차

A suspension of 3-bromo-8-(2,6-dichloro-3-nitrobenzyloxy)-2-methylimidazo[1,2-a]pyridine (215 mg) and iron (powder, 84 mg) in a mixture of conc. hydrochloric acid (1 ml) and methanol (1 ml) was refluxed for half an hour. The cooled mixture was poured into an ice water (15 ml). The precipitates were collected and washed with water to give 8-(3-amino-2,6-dichlorobenzyloxy)-3-bromo-2-methylimidazo[1,2-a]pyridine dihydrochloride (140 mg) as an off-white solid.

후처리

  1. temperaturewas refluxed for half an hour
  2. customThe precipitates were collected
  3. washwashed with water

출처 및 근거

ORD 기록
ord-2bf8fdcca0864bd298dd8181c3483414
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750699

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