Sodium Hydroxide → 1,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

HRID 1290461노트

반응식

HRID 1290461 반응식
C(O)(=O)C(O)=O.[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])([CH3:10])([CH3:9])[CH3:8].[OH-].[Na+]>C1(C)C=CC=CC=1>[C:7]([O:11][C:12]([NH:14][C@H:15]([C@@H:23]([OH:34])[CH2:24][C@@H:25]([NH2:33])[CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)=[O:13])([CH3:10])([CH3:8])[CH3:9]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 70191891HCID 70191891, 화합물

생성물 1

HCID 103178781,1-Dimethylethyl N-[(1S,2S,4S)-4-amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]carbamate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(2S,3S,5S)-2-tert-Butoxycarbonylamino-3-hydroxy-5-amino-1,6-diphenylhexane oxalate (500 mg, 1.05 mmol) obtained in Example 43 (A) was suspended in toluene (5 ml). An aqueous solution (5 ml) of NaOH (200 mg) was added thereto and the mixture was vigorously stirred, then separated. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The desiccant was filtered off, and the filtrate was concentrated to give the desired compound as colorless crystals. Yield: 340 mg (84%).

후처리

  1. customseparated
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. filtrationThe desiccant was filtered off
  5. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-6aaf6d2079734523a1e25d5a42c75656
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05750717

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