Potassium → 4-Methyl-6-nitro-1H-indole

HRID 1290565노트

반응식

HRID 1290565 반응식
[K].C(OCC)(=O)C([O-])=O.[CH3:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][C:12]=1[N:21]=[CH:22]OC>CN(C)C=O>[CH3:17][C:16]1[CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=[C:12]2[C:11]=1[CH:10]=[CH:22][NH:21]2

참가 물질

5

반응물 3

HCID 5462222PotassiumHCID 21218303HCID 21218303, 화합물HCID 21943339Ethanedioic acid, monoethyl ester

생성물 1

HCID 212182864-Methyl-6-nitro-1H-indole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

반응 조건

온도
40 °C

실험 절차

A solution of 31 g of potassium ethoxylate, 51 ml of ethyl oxalate and 0.25 l of dimethylformamide is added to a solution of methyl N-(2,3-dimethyl-5-nitrophenyl)formimidate (52 g) in 0.37 l of dimethylformamide. The temperature of the mixture is raised to 40° C. for 3 hours. The precipitate is filtered off and washed with water. The precipitate is taken up in hot isopropyl ether and then filtration is carried out.

후처리

  1. filtrationThe precipitate is filtered off
  2. washwashed with water
  3. filtrationfiltration

출처 및 근거

ORD 기록
ord-22a241a7c279457799d51da4b15e6f1e
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05752982

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