Methane → HCID 18916577, 화합물

HRID 1290654노트

반응식

HRID 1290654 반응식
[CH3:1][N:2]1[CH:10]2[CH:6]([CH2:7][C:8]([P:15]([OH:18])(=[O:17])[OH:16])([P:11]([OH:14])(=[O:13])[OH:12])[CH2:9]2)[CH2:5][CH2:4][CH2:3]1.[C:19]([S:22][CH2:23][CH2:24][Br:25])(=[O:21])[CH3:20].C>O.CS(C)=O>[Br-:25].[P:11]([C:8]1([P:15]([OH:16])([OH:18])=[O:17])[CH2:9][CH:10]2[CH:6]([CH2:5][CH2:4][CH2:3][N+:2]2([CH2:24][CH2:23][S:22][C:19](=[O:21])[CH3:20])[CH3:1])[CH2:7]1)([OH:12])([OH:14])=[O:13]

참가 물질

6

반응물 3

HCID 297MethaneHCID 5230361-[(2-Bromoethyl)sulfanyl]ethan-1-oneHCID 14518763HCID 14518763, 화합물

생성물 1

HCID 18916577HCID 18916577, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

Octahydro-1-methyl-1-pyrindine-6,6-diphosphonic acid (0.12 mmol) is dissolved in a mixture of water (25 ml) and DMSO (5 ml). To this is added 2-acetylthioethyl bromide (0.60 mmol) and the reaction mixture is heated at 60° for 24 hours. The reaction mixture is cooled, treated with charcoal, filtered and concentrated under reduced pressure. The crude residue is triturated with diethylether and the product can be obtained by recrystallizing the solid residue in water and isopropanol.

후처리

  1. temperaturethe reaction mixture is heated at 60° for 24 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude residue is triturated with diethylether
  6. customthe product can be obtained
  7. customby recrystallizing the solid residue in water

출처 및 근거

ORD 기록
ord-f301d39577144ce3ae58d6ad92ae7d2d
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753634

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