Cysteamine → HCID 22592849, 화합물

HRID 1290697노트

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HRID 1290697 반응식
Br[CH:2]([CH2:10]Br)[C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[SH:12][CH2:13][CH2:14][NH2:15].C(N(CC)CC)C.C(Cl)(Cl)Cl>C1C=CC=CC=1>[S:12]1[CH2:13][CH2:14][NH:15][CH:2]([C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4])[CH2:10]1

참가 물질

6

반응물 4

HCID 6058CysteamineHCID 6212ChloroformHCID 8471TriethylamineHCID 545325tert-Butyl 2,3-dibromopropanoate

생성물 1

HCID 22592849HCID 22592849, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Preferably, t-butyl 2,3-dibromopropionate prepared according to J. Perkin Trans I, p. 1321 (1973) is treated with 2-mercaptoethylamine and triethylamine in a suitable solvent, such as a mixture of chloroform and benzene, to provide t-butyl tetrahydro-2H-1,4-thiazine-3-carboxylate, which upon reaction with a compound of the formula V under suitable conditions, such as in the presence of triethylamine in dichloromethane solution at 25° C., provides compounds of the formula II-c. Oxidation of this material with a suitable oxidizer, such as sodium perborate or m-chloroperbenzoic acid, provides the corresponding sulfoxide, preferably as a single diastereomer.

출처 및 근거

ORD 기록
ord-5f3e20ce42644712b981f5ff5c7e84b2
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753653

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