Water → 2-(Pyridin-2-YL)benzoic acid

HRID 1290942

반응식

HRID 1290942 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=[O:10].[OH-].[Na+].O>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=1[C:9]([OH:11])=[O:10]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13417093Methyl 2-(2-pyridinyl)benzoate

생성물 1

HCID 157331752-(Pyridin-2-YL)benzoic acid수율 89.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 3.0 g of methyl 2-(2-pyridinyl)benzoate and 600 mg of sodium hydroxide in 50 ml of 9:1 methanol:water is refluxed for 4 hours. The reaction mixture is concentrated in vacuo and the residue dissolved in 50 ml of cold water. The solution is neutralized with glacial acetic acid and the resulting product filtered, washed with water, and dried to give 2.5 g of the desired product:M+1=200.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. dissolutionthe residue dissolved in 50 ml of cold water
  3. filtrationthe resulting product filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-913a93ba2ddf493880cb0f4d3bcc811c
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753648

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