Butanal → 1-But-1-enylpyrrolidine

HRID 129100노트

반응식

HRID 129100 반응식
[CH:1](=O)[CH2:2][CH2:3][CH3:4].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[N:6]1([CH:7]=[CH:8][CH2:9][CH3:10])[CH2:4][CH2:3][CH2:2][CH2:1]1

참가 물질

5

반응물 3

HCID 261ButanalHCID 11430Potassium CarbonateHCID 31268Pyrrolidine

생성물 1

HCID 1396491-But-1-enylpyrrolidine수율 97%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

108 g of freshly distilled butyraldehyde were added dropwise at 0° C. to a mixture of 213 g of pyrrolidine and 213 g of potassium carbonate. The mixture was allowed to stand overnight at room temperature, diluted with 300 ml of toluene, and the residue was filtered off. The filtrate was then subjected to vacuum distillation at 85° to 90° C. (80 mbar), giving 102 g of 97% pure 1-pyrrolidinobutene, which corresponds to 63.7% of the theoretical yield).

후처리

  1. filtrationthe residue was filtered off
  2. distillationThe filtrate was then subjected to vacuum distillation at 85° to 90° C. (80 mbar)

출처 및 근거

ORD 기록
ord-d3697e5b00e64347a24e9c7a729501b3
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466800

반응 노트

불러오는 중…