2-Amino-2-methyl-1-propanol → Tert-butyl 2-(1-hydroxy-2-methylpropan-2-yl)hydrazine-1-carboxylate

HRID 12913

반응식

HRID 12913 반응식
[C:1]([O:5][C:6]([N:8]1C(C2C=CC(C#N)=CC=2)O1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:19][C:20]([CH3:24])([CH3:23])[CH2:21][OH:22]>C(OCC)C>[C:1]([O:5][C:6]([NH:8][NH:19][C:20]([CH3:24])([CH3:23])[CH2:21][OH:22])=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

4

반응물 2

HCID 118072-Amino-2-methyl-1-propanolHCID 2725038N-Boc-3-(4-cyanophenyl)oxaziridine

생성물 1

HCID 54541694Tert-butyl 2-(1-hydroxy-2-methylpropan-2-yl)hydrazine-1-carboxylate수율 40%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of N-(tert-butoxycarbonyl)-3-(4-cyanophenyl)-oxaziridine (CAS #: 150884-56-3, purchased from Acros, 5.17 g, 21 mmol) in anhydrous diethyl ether (20 mL) was added to a solution of 2-amino-2-methyl-propan-1-ol (1.78 g, 20 mmol) in anhydrous diethyl ether (20 mL) at room temperature. The reaction mixture stirred at room temperature for 2 hours. Diethyl ether was evaporated under reduced pressure and the residue was purified by flash chromatography eluting with a gradient of 3-5% methanol/dichloromethane to give N′-(2-hydroxy-1,1-dimethyl-ethyl)-hydrazinecarboxylic acid tert-butyl ester (1.63 g, 40%) which was used without further purification.

후처리

  1. customDiethyl ether was evaporated under reduced pressure
  2. customthe residue was purified by flash chromatography
  3. washeluting with a gradient of 3-5% methanol/dichloromethane

출처 및 근거

ORD 기록
ord-279d0f43f58a4171a279e21137b58bb2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728029B2

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