Methyl iodide → 5-ethyl-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
반응식
[K].[CH2:2]([N:4]1[C:9](=[O:10])[C:8]2[CH:11]=[N:12][NH:13][C:7]=2[N:6]=[C:5]1[SH:14])[CH3:3].[CH3:15]I>CN(C=O)C>[CH2:2]([N:4]1[C:9](=[O:10])[C:8]2[CH:11]=[N:12][NH:13][C:7]=2[N:6]=[C:5]1[S:14][CH3:15])[CH3:3]참가 물질
4
실험 절차
To a solution of 5-ethyl-6-mercapto-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one potassium (5.0 g) in DMF (40 ml) was added methyl iodide (3.65 g) and the mixture was stirred for 1 hour. This reaction mixture was concentrated and the residue was diluted with water. The resulting crystals were collected by filtration and rinsed with water to provide 5-ethyl-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one as colorless solid (2.908 g).
후처리
- concentrationThis reaction mixture was concentrated
- additionthe residue was diluted with water
- filtrationThe resulting crystals were collected by filtration
- washrinsed with water
출처 및 근거
- ORD 기록
- ord-ed8c2ba196554693b96af0a07ebe6175
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05753664
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