N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 129158노트

반응식

HRID 129158 반응식
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

참가 물질

5

반응물 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

생성물 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazolone수율 89.4%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 887Methanol용매HCID 962Water용매

실험 절차

This urea (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water, and 300 ml of 0.48M hydrochloric acid was added thereto and the resulting mixture was stirred for three days at room temperature. The reaction solution was concentrated under reduced pressure. The crystals thus separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone as a colorless powder.

후처리

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customThe crystals thus separated out
  4. washwere washed with a mixture of water and methanol (5:1)

출처 및 근거

ORD 기록
ord-8d82a73fa4cf4fb9bf2139f0d84dd2a9
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466820

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