Sodium Dithionite → 2,2'-Bithiophene-5-carboxylic acid

HRID 1291580

반응식

HRID 1291580 반응식
[O-]Cl.[Na+].[C:4]([C:7]1[S:11][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][CH:8]=1)(=[O:6])C.[O-:17]S(S([O-])=O)=O.[Na+].[Na+]>>[C:4]([C:7]1[S:11][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][CH:8]=1)([OH:6])=[O:17]

참가 물질

4

반응물 3

HCID 24489Sodium DithioniteHCID 6064225-Acetyl-2,2'-bithienylHCID 23665760Sodium Hypochlorite

생성물 1

HCID 1509652,2'-Bithiophene-5-carboxylic acid

실험 절차

35 ml of NaOCl solution was heated to 55° C. and 5acetyl-2,2'-bithiophene was then added and stirred at 60°-70° C. for 2 hours. Then the reaction solution was cooled by ice bath and aqueous Na2S2O4 solution was added for removing the residual NaOCl. The reaction mixture was acidified by HCl(aq) and filtered to obtain golden product. The product was further recrystallized with 95% ethanol. The melting point of the product was 183-184%.

후처리

  1. temperatureThen the reaction solution was cooled by ice bath
  2. customfor removing the residual NaOCl
  3. filtrationfiltered
  4. customto obtain golden product
  5. customThe product was further recrystallized with 95% ethanol

출처 및 근거

ORD 기록
ord-085b021deec3432fa8b44fe999245988
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05753692

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