Hydrochloric Acid → {2-[4-(Trifluoromethyl)phenyl]hydrazinylidene}acetic acid

HRID 129163

반응식

HRID 129163 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.Cl.O.[C:15]([OH:19])(=[O:18])[CH:16]=O>O>[F:1][C:2]([F:11])([F:12])[C:3]1[CH:4]=[CH:5][C:6]([NH:9][N:10]=[CH:16][C:15]([OH:19])=[O:18])=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1362004-(Trifluoromethyl)phenylhydrazineHCID 15620607Glyoxylic acid, monohydrate

생성물 1

HCID 69587423{2-[4-(Trifluoromethyl)phenyl]hydrazinylidene}acetic acid수율 95%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 5.0 g of 4-(trifluoromethyl)phenylhydrazine (28.4 mmol), 31 ml of water and 3.1 ml of concentrated hydrochloric acid was added 2.9 g of glyoxylic acid-hydrate (31.4 mmol), and the mixture was stirred for one hour at room temperature. The precipitates thus separated out was collected by filtration, washed with water and dried over phosphorus pentoxide to give 6.26 g of 4-(trifluoromethyl)phenylhydrazonoacetic acid (95%) as a pale yellow powder.

후처리

  1. customThe precipitates thus
  2. customseparated out
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. dry with materialdried over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-4e10d66f2d2048fa892f7bfb5cdb5d3a
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05466820

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