4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 1292243노트

반응식

HRID 1292243 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

생성물 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL수율 79.5%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of 4-bromobiphenyl (50 g, 0.21 mol) in chloroform (200 mL) was added dropwise at room temperature chlorosulfonic acid (32.5 g, 0.28 mol). The solution was stirred at room temperature for 16 hours, then diluted with hexanes (200 mL). The precipitate was collected by filtration and washed with hexanes to give 4'-bromobiphenyl-4-sulfonic acid (52.3 g, 79%) as a white solid. The crude product was used in the next step without further characterization.

후처리

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with hexanes

출처 및 근거

ORD 기록
ord-a769a92bc2f64a84af08b23594258d81
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756545

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