Hydrochloric Acid → 2-Methoxy-4-(4-piperidyloxy)benzoic acid
반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl>C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]참가 물질
4
실험 절차
2-Methoxy-4-(1-Boc-4-piperidyloxy)benzoic acid (0.79 g, 2.24 mmol) was dissolved in ethyl acetate (15 ml). The solution was cooled in ice and saturated with HCl gas, then stirred 30 min in the cold. The mixture was evaporated in vacuo and the residue concentrated from ether three times to give 2-methoxy-4-(4-piperidyloxy)benzoic acid.
후처리
- customThe mixture was evaporated in vacuo
- concentrationthe residue concentrated from ether three times
출처 및 근거
- ORD 기록
- ord-f036814dc39d4a55a79d10b483490ec1
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05756504
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