반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3]C=1.SCC[C:11]([OH:13])=[O:12].[CH3:14]C1C=CC2C(=CC=C(C)C=2)C=1.CC(C1C=CC(O)=CC=1)=O>>[CH3:14][O:13][C:11]([CH:5]1[CH2:4][CH2:3][O:7][CH2:1][CH2:6]1)=[O:12]참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
A mixture of 94 grams (1.0 mol) of phenol, 5.31 g (0.0500 mol) of 3-mercaptopropionic acid, 10 g of LEWATIT BE ion exchange resin and 1.0 g of 2,6-dimethylnaphthalene (internal standard for liquid chromatography analysis) was heated to about 65° C. in a round bottom flack equipped with a distillation setup, an internal thermometer and a mechanical stirrer. The solution was continuously sparged with nitrogen (using a dip tube) to remove the water. To this mixture was added 11.35 g (0.8336 mol) of 4-hydroxyacetophenone. The mixture was stirred at about 65° C with the nitrogen sparge for about 8 hrs. The THPE was isolated by precipitation with methylene chloride (4 mL/1 g of reaction mixture) and the yield is given in Table III.
후처리
- customequipped with a distillation setup
- customThe solution was continuously sparged with nitrogen (using a dip tube)
- customto remove the water
- customsparge for about 8 hrs
출처 및 근거
- ORD 기록
- ord-2ac373a1a2fe408096c601926017e365
- 출처 데이터셋
- uspto-grants-1998_05
- 특허 번호
- US05756781
연결된 노트
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