Formaldehyde → HCID 21834627, 화합물

HRID 1292668노트

반응식

HRID 1292668 반응식
[CH2:1]([NH:8][CH2:9][CH2:10][CH:11]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C=O.[C:26]([BH3-])#N.[Na+]>CC#N.O>[CH2:1]([N:8]([CH2:9][CH2:10][CH:11]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:26])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 8032053HCID 8032053, 화합물

생성물 1

HCID 21834627HCID 21834627, 화합물

시약·촉매·용매 1

HCID 18373917Acetonitrile--water (1/1)용매

실험 절차

To a solution of N-benzyl-3,3-diphenylpropylamine (1.29 g, 4.30 mmol) and 30% aq. formaldehyde (1.50 ml, 20 mmol) in CH3CN:H2O (2:1, v/v, 40 ml) was added sodium cyanoborohydride (563 mg, 8.96 mmol) at 0° C. The reaction was allowed to warm to room temperature and stirred for 90 min. The organic solvent was evaporated, and the residue diluted with water and extracted with CH2Cl2. The organic extracts were washed with brine, dried (Na2SO4) and the solvent evaporated in vacuo to afford the title compound as an oil.

후처리

  1. customThe organic solvent was evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with CH2Cl2
  4. washThe organic extracts were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customthe solvent evaporated in vacuo

출처 및 근거

ORD 기록
ord-a36353313b1a478bbde77c19b719fd2c
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05756528

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