Water → (4-Ethoxy-6-trifluoromethylpyrimidin-5-yl)-methanol

HRID 1292825노트

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HRID 1292825 반응식
[CH2:1]([O:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([C:12]([F:15])([F:14])[F:13])[N:7]=[CH:6][N:5]=1)[CH3:2].[BH4-].[Na+].O>CO>[CH2:1]([O:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([C:12]([F:14])([F:15])[F:13])[N:7]=[CH:6][N:5]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 178628784-Ethoxy-6-(trifluoromethyl)pyrimidine-5-carbaldehyde

생성물 1

HCID 17862901(4-Ethoxy-6-trifluoromethylpyrimidin-5-yl)-methanol수율 98.7%

시약·촉매·용매 1

HCID 887Methanol용매2회

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온도
0 °C

실험 절차

A solution of 3.82 g (17.2 mmoles) of 4-ethoxy-6-trifluoromethylpyrimidine-5-carboaldehyde dissolved in 50 ml of methanol was added, with ice-cooling, to a solution of 1.7 g (45.7 mmoles) of sodium borohydride dissolved in 50 ml of methanol. The mixture was stirred at 0° C. for 1 hour to give rise to a reaction. After the completion of the reaction, the reaction mixture was poured into water, followed by extraction with ethyl acetate. The resulting organic layer was washed with an aqueous sodium chloride solution and then dried over anhydrous magnesium sulfate. The resulting solution was subjected to vacuum distillation to remove the solvent contained therein, to obtain 3.77 g (yield: 97.8%) of (4-ethoxy-6-trifluoromethylpyrimidin-5-yl)-methanol

후처리

  1. additionwas added, with ice-
  2. customto give rise
  3. customto a reaction
  4. customAfter the completion of the reaction
  5. extractionfollowed by extraction with ethyl acetate
  6. washThe resulting organic layer was washed with an aqueous sodium chloride solution
  7. dry with materialdried over anhydrous magnesium sulfate
  8. distillationThe resulting solution was subjected to vacuum distillation
  9. customto remove the solvent

출처 및 근거

ORD 기록
ord-1dca1db12fec49bcb7ba804f9161aaab
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238689B2

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