Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

HRID 1292861

반응식

HRID 1292861 반응식
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1.[NH3:22]>>[Cl:1][C:2]1[N:11]=[C:10]([NH2:22])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 588201952,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline

생성물 1

HCID 589051302-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

실험 절차

Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).

후처리

  1. customthe solution formed after 30 min
  2. filtrationThe precipitate was filtered
  3. customthe concentrated filtrate triturated with EtOAc

출처 및 근거

ORD 기록
ord-9a55840aab77422bbbf1d8a693a522b8
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238698B2

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