Chloroacetone → 2-Methylimidazo[1,2-a]pyridine

HRID 1293140

반응식

HRID 1293140 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.Cl[CH2:9][C:10](=O)[CH3:11]>C(O)C>[CH3:11][C:10]1[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]2[CH:9]=1

참가 물질

4

반응물 2

HCID 6571ChloroacetoneHCID 104392-Aminopyridine

생성물 1

HCID 1367422-Methylimidazo[1,2-a]pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-aminopyridine (9.4 g), chloroacetone (9.5 ml), and ethanol (25 ml) was heated and stirred for 5 hours on an oil bath at 100° C. After that, the reaction solution was concentrated under reduced pressure, and extracted with ethyl acetate-aqueous potassium carbonate solution. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to a column chromatography using NH silica gel with 20 to 30% ethyl acetate/hexane to yield the title compound (5.5 g).

후처리

  1. temperaturewas heated
  2. concentrationAfter that, the reaction solution was concentrated under reduced pressure
  3. extractionextracted with ethyl acetate-aqueous potassium carbonate solution
  4. washThe organic layer was washed with saturated aqueous sodium chloride solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9ad361289cd24ef7b6f1af38a0deef44
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238720B2

연결된 노트

불러오는 중…