Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → 8-Azabicyclo[3.2.1]octane hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 1-Chloroethyl chloroformate | HCID 521305 | — |
| 반응물 | Tropane | HCID 637986 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 8-Azabicyclo[3.2.1]octane hydrochloride | HCID 522272 | — |
반응 단계
A mixture of tropane (900 mg), 1-chloroethyl chloroformate (1 ml), and toluene (20 ml) was heated and refluxed for 6 hours. After that, methanol (10 ml) was added to the reaction solution, and further refluxed for 4 hours. The solvent was distilled to yield the title compound (850 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07238720B2 |
| 출처 데이터셋 | uspto-grants-2007_07 |
| ORD ID | ord-fe22afe8ae504626af06b4ebceeec28c |
| 출처 메모 | uspto-grants-2007_07 |