Water → 1-Tosylpyrozole

HRID 1293150

반응식

HRID 1293150 반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1.O>N1C=CC=CC=1>[C:6]1([CH3:16])[CH:11]=[CH:10][C:9]([S:12]([N:1]2[CH:5]=[CH:4][CH:3]=[N:2]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 1048PyrazoleHCID 73974-Toluenesulfonyl chloride

생성물 1

HCID 3207501-Tosylpyrozole수율 15.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
130 °C

실험 절차

A suspension of pyrazole (1 g) and 4-toluenesulfonyl chloride (2.8 g) in pyridine (10 ml) was stirred at 130° C. for 1 hour. After the reaction mixture was cooled, water was added to the reaction mixture, resulting in a white suspension. The resultant suspension was filtered, and the obtained white solids were washed three times with water. Drying at room temperature under reduced pressure gave white solids (500 mg).

후처리

  1. temperatureAfter the reaction mixture was cooled
  2. customresulting in a white suspension
  3. filtrationThe resultant suspension was filtered
  4. washthe obtained white solids were washed three times with water
  5. customDrying at room temperature under reduced pressure

출처 및 근거

ORD 기록
ord-27d2bf1fc6a949e3be428f9784d16fe0
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238720B2

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