4-Aminophenol → N-[4-(3-Amino-4-nitrophenoxy)phenyl]acetamide

HRID 1294052노트

반응식

HRID 1294052 반응식
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+](C1C=C[C:24]([O:25]C2C=CC(N)=C([N+]([O-])=O)C=2)=[CH:23]C=1)([O-])=O.[NH2:38]C1C=CC(O)=CC=1.C([S-])#N.[K+].BrBr>>[C:24]([NH:13][C:12]1[CH:14]=[CH:15][C:9]([O:8][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[C:17]([CH:16]=2)[NH2:38])=[CH:10][CH:11]=1)(=[O:25])[CH3:23]

참가 물질

6

반응물 5

HCID 4034-AminophenolHCID 24408BromineHCID 802514-(4-Nitrophenoxy)benzenamineHCID 516872Potassium thiocyanateHCID 12032722Benzenamine, 2-nitro-4-(4-nitrophenoxy)-

생성물 1

HCID 13705240N-[4-(3-Amino-4-nitrophenoxy)phenyl]acetamide

실험 절차

Compounds of Formula I, wherein D is CH, T is CH, M is C, Q is S, and q is 0, can be prepared according to the synthetic sequence shown in Scheme 7 and further detailed in the Examples section following. 4-(4-Nitrophenoxy)aniline (2), derived from (1) and 4-aminophenol, was cyclized with KSCN and Br2 in the presence of acid to provide thiazole (3). Subsequent reaction with ClCO2Me or butylisocyante (BuNCO) to give (4), followed by reduction with SnCl2 to give (5) and finally coupling with isocyanate afforded (6).

후처리

  1. customcan be prepared

출처 및 근거

ORD 기록
ord-4814e6921c6e408d97e6a6e8c932b07a
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238813B2

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