Methanol → 4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol

HRID 1294221노트

반응식

HRID 1294221 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=2)=[N:4][C:3]=1[CH2:17][O:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=[O:24])=[CH:21][CH:20]=1.O1CCCC1.CO.[BH4-].[Na+]>O>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=2)=[N:4][C:3]=1[CH2:17][O:18][C:19]1[CH:20]=[CH:21][C:22]([CH2:23][OH:24])=[CH:25][CH:26]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 185461594-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde

생성물 1

HCID 688833594-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol수율 95.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzaldehyde (6.00 g), tetrahydrofuran (80 mL) and methanol (20 mL) was gradually added sodium borohydride (330 mg) at room temperature. After stirring for 30 min., water was added to the reaction mixture, and the precipitated crystals were collected by filtration and recrystallized from acetone-methanol to give colorless prism crystals (5.76 g, 95%) of 4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]benzyl alcohol. melting point: 181-182° C.

후처리

  1. customat room temperature
  2. filtrationthe precipitated crystals were collected by filtration
  3. customrecrystallized from acetone-methanol

출처 및 근거

ORD 기록
ord-81a421e52c1a488eaaff4402bbab01ec
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238716B2

반응 노트

불러오는 중…