Benzoic Acid → rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

HRID 129429노트

반응식

HRID 129429 반응식
C([N:9]1[CH2:17][C@@H:16]2[C@@H:11]([N:12]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH2:13][CH2:14][O:15]2)[CH2:10]1)(=O)C1C=CC=CC=1.Cl.C(O)(=O)C1C=CC=CC=1>O>[CH2:18]([N:12]1[C@@H:11]2[C@@H:16]([CH2:17][NH:9][CH2:10]2)[O:15][CH2:14][CH2:13]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 243Benzoic AcidHCID 313Hydrochloric AcidHCID 53682667cis-8-Benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

생성물 1

HCID 10856960rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

91 g (0.265 mol) of cis-8-benzoyl-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are refluxed overnight with 200 ml of concentrated hydrochloric acid and 140 ml of water. The batch is cooled and the benzoic acid suctioned off. The batch is concentrated to half its original volume, adjusted to alkalinity with potassium carbonate, extracted with chloroform, dried over potassium carbonate, concentrated, and distilled.

후처리

  1. temperatureThe batch is cooled
  2. concentrationThe batch is concentrated to half its original volume
  3. extractionextracted with chloroform
  4. dry with materialdried over potassium carbonate
  5. concentrationconcentrated
  6. distillationdistilled

출처 및 근거

ORD 기록
ord-e4fddf6a3d634a8ea900c4f13e228d4e
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05468742

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