Hydrochloric Acid → 3-[4-[[4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzyl]sulfanyl]phenyl]propionic acid

HRID 1294294

반응식

HRID 1294294 반응식
Cl[CH2:2][C:3]1[CH:22]=[CH:21][C:6]([O:7][CH2:8][C:9]2[N:10]=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:12][C:13]=2[CH3:14])=[CH:5][CH:4]=1.[SH:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[CH:26][CH:25]=1.C(N(CC)CC)C.Cl>O.CN(C)C=O>[CH3:14][C:13]1[O:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:10][C:9]=1[CH2:8][O:7][C:6]1[CH:21]=[CH:22][C:3]([CH2:2][S:23][C:24]2[CH:25]=[CH:26][C:27]([CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[CH:28][CH:29]=2)=[CH:4][CH:5]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 5797844-Mercaptohydrocinnamic AcidHCID 109469404-(4-Chloromethylphenoxy)methyl-5-methyl-2-phenyloxazole

생성물 1

HCID 688845593-[4-[[4-[(5-Methyl-2-phenyl-4-oxazolyl)methoxy]benzyl]sulfanyl]phenyl]propionic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4-(4-chloromethylphenoxymethyl)-5-methyl-2-phenyloxazole (1.73 g), 3-(4-mercaptophenyl)propionic acid (1.00 g), triethylamine (1.22 g) and N,N-dimethylformamide (20 mL) was stirred at room temperature for 2 hrs. The reaction mixture was poured into water, acidified with 2N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated to give crystals of 3-[4-[[4-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]benzyl]sulfanyl]phenyl]propionic acid. Recrystallization from ethyl acetate gave colorless prism crystals (1.85 g, 73%). melting point: 157-158° C.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a3eea87b9f6f49dfae639f1839b55d64
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238716B2

연결된 노트

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