Diazomethane → (+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

HRID 1294390노트

반응식

HRID 1294390 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([OH:13])=[O:12])=[C:4]([F:14])[CH:3]=1.[N+](=[CH2:17])=[N-]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([O:13][CH3:17])=[O:12])=[C:4]([F:14])[CH:3]=1

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 438103082-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid

생성물 1

HCID 69157593(+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (+)-2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid from step 7 (1 eq) in methylenechloride was added an ethereal solution of diazomethane until reaction is completed by TLC. The resulting mixture was concentrated. The crude ester was used as such in the next step.

후처리

  1. customuntil reaction
  2. concentrationThe resulting mixture was concentrated

출처 및 근거

ORD 기록
ord-f37aadaa08774703a1471ec380b5d890
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07238706B2

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