Hydrochloric Acid → Dapivirine HCl

HRID 1294426노트

반응식

HRID 1294426 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[N:12]=1.[ClH:26].CC(O)C>C(O)C>[ClH:26].[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]2[CH:25]=[CH:24][C:21]([C:22]#[N:23])=[CH:20][CH:19]=2)[N:12]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 214347Dapivirine

생성물 1

HCID 22398432Dapivirine HCl수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino]benzonitrile (0.0015 mol) was stirred in boiling ethanol (8 ml). 6 M HCl in 2-propanol (0.0015 mol) was added and the salt was allowed to crystallize out overnight at room temperature. The precipitate was filtered off, washed with 2-propanol and dried, yielding 0.47 g (86%) of 4-[[4-[(2,4,6-trimethyl-phenyl)amino]-2-pyrimidinyl]amino]benzonitrile hydrochloride (1:1) (comp. 31).

후처리

  1. customto crystallize out overnight at room temperature
  2. filtrationThe precipitate was filtered off
  3. washwashed with 2-propanol
  4. customdried

출처 및 근거

ORD 기록
ord-b25071f9a70f4d6985e614064e8bc147
출처 데이터셋
uspto-grants-2007_07
특허 번호
US07241458B1

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